In Theaters: August 19th, 2011

|
|
|
|
|
|
| Name | Role |
|---|---|
| Rowan Blanchard | Rebecca Wilson |
| Mason Cook | Cecil Wilson |
| Alexa Vega | Carmen Cortez |
| Daryl Sabara | Juni Cortez |
| Danny Trejo | Uncle Machete |
| Belle Solorzano | Spy Baby |
| Genny Solorzano | Spy Baby |
| Ricky Gervais | Argonaut (voice) |
| Elmo | Argonaut |
| Jett Good | Young Danger |
| Chuck Cureau | News Anchor |
| Albert Im | Head Scientist |
| Wray Crawford | Editor / Cameraman |
| Jonathan Breck | Wilbur's Boss |
| Alcides Dias | OSS Agent #1 (as Al 'Train' Dias) |
| Roger Edwards | OSS Agent Adams |
| Angela Lanza | Female OSS Agent |
| Chad Guerrero | Henchman in Van |
| Marci Madison | Agent Fine |
| Desmond Aldridge | Technician |
| Dalton Gray | Student |
| Miles Marmolejo | Student |
| Wil Pollard | Henchmen |